Estudo retrospectivo de radiodermatite em pacientes com câncer de mama: uma experiência institucional privada e pública

Andrea Moraes Ipiranga, Cintia Yolette Urbano Pauxis Aben-Athar, Renata Glaucia Barros da Silva Lopes, Heryvelton Lima de Freitas, Aline Maria Pereira Cruz Ramos

Resumo


 

Introdução: A radiodermatite aguda é comumente observada em pacientes com câncer de mama submetidas à radioterapia. Objetivo: Comparar a radiodermatite aguda em mulheres tratadas com radioterapia convencional ou com intensidade modulada em dois Centros de Radioterapia (intituição pública e privada). Métodos: Estudo transversal, retrospectivo e descritivo, desenvolvido em dois hospitais da cidade de Belém/PA, que avaliou 343 mulheres entre 2012 e 2015. Resultados: Houve radiodermatite aguda nos dois Centros de Radioterapia analisados, coincidindo entre a 16º à 20º aplicação independentemente do tipo de tecnologia utilizada. A maioria das lesões foram classificadas como RTOG1 e interrupção do tratamento por 1 semana ocorreu na instituição pública. Quanto ao manejo profilático, as instituições divergiram na indicação da compressão com chá de camomila e creme a base de aloé vera, e coincidiram no tratamento farmacológico com esteróide e antibiótico tópico. Conclusão: Os resultados evidenciaram radiodermatite aguda em ambas instituições, independente da técnica aplicada.

Palavras-chave: neoplasia de mama, radioterapia, radiodermatite.


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Referências


Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M et al. Estimating the Global Cancer Incidence and Mortality in 2018: Globocan Sources and Methods. Int J Cancer 2019;(8):1941-53. https://doi.org/10.1002/ijc.31937

Wei J, Meng L, Hou X, Qu C, Wang B, Xin Y et al. Radiation-induced skin reactions: mechanism and treatment. Cancer Manag Res 2019;(11):167-77. https://doi.org/ 10.2147/CMAR.S188655

Bray FN, Simmons BJ, Wolfson AH, Nouri K. Acute and chronic cutaneous reactions to ionizing radiation therapy. Dermatol Ther (Heidelb) 2016;(2):185-206. https://doi.org/10.1007/s13555-016-0120-y

Fuzissaki MA, Paiva CE, Oliveira MA, Canto PPL, Maia YCP. The impact of radiodermatitis on breast cancer patients' quality of life during radiotherapy: a prospective cohort study. J Pain Symptom Manage 2019;(58):92-9. https://doi.org/10.1016/j.jpainsymman.2019.03.017

Haruna F, Lipsett A, Marignol L. Topical management of acute radiation dermatitis in breast cancer patients: a systematic review and meta-analysis. Anticancer Res 2017;(10):5343-53. https://doi.org/10.21873/anticanres.11960

Kitajima M, Mikami K, Noto Y, Itaki C, Fukushi Y, Hirota Y et al. Quantitative assessment of radiodermatitis through a non-invasive objective procedure in patients with breast cancer. Mol Clin Oncol 2020;(12):89-93. https://doi.org/10.3892/mco.2019.1948

Lee T, Sung KC, Chao PJ, Huang YJ, Lan JH, Wu HY. Relationships among patient characteristics, irradiation treatment planning parameters, and treatment toxicity of acute radiation dermatitis after breast hybrid intensity modulation radiation therapy. PloS One 2018;(13):1-14. https://doi.org/10.1371/journal.pone.0200192

Kole A, Kole L, Moran M. Acute radiation dermatitis in breast cancer patients: challenges and solutions. Breast Cancer - Targets and Therapy 2017;(9):313-23. https://doi.org/10.2147/BCTT.S109763

Seité S, Bensadoun R, Mazer J. Prevention and treatment of acute and chronic radiodermatitis. Breast Cancer: Targets and Therapy 2017;(9):551-7.

Borm KJ, Loos M, Oechsner M, Mayinger MC, Paepke D, Kiechle MB et al. Acute radiodermatitis in modern adjuvant 3D conformal radiotherapy for breast cancer - the impact of dose distribution and patient related factors. Radiat Oncol 2018;(13):218. https://doi.org/10.1186%2Fs13014-018-1160-5

Mishra R, Khurana R, Mishra H, Rastogi M, Hadi R. Retrospective analysis of efficacy and toxicity of hypo-fractionated radiotherapy in breast carcinoma. J Clin Diagn Res 2016;(10):01-03. https://doi.org/10.7860/JCDR/2016/20769.8350

Yee C, Asthana R, Leung E, De Angelis C, Chow E. Radiation-induced skin toxicity in breast cancer patients: a systematic review of randomized trials. Clin Breast Cancer 2018;(5):825-40. https://doi.org/10.1016/j.clbc.2018.06.015

Tortorelli G, Di Murro L, Barbarino R et al. Standard or hypofractionated radiotherapy in the postoperative treatment of breast cancer: a retrospective analysis of acute skin toxicity and dose inhomogeneities. BMC Cancer 2013;(13):230. https://doi.org/10.1186/1471-2407-13-230

Partl R, Lehner J, Winkler P, Kapp KS. Testing the feasibility of augmented digital skin imaging to objectively compare the efficacy of topical treatments for radiodermatitis. PloS One 2019;(14). https://doi.org/10.1371/journal.pone.0218018

Gomes V, Nonato R, Gomes S, Joaquim M, Lago E, Nicolau R. Effects of Matricaria Recutita (L.) in the treatment of oral mucositis. Scientific World Journal 2018;(12):1-8. https://doi.org/10.1155/2018/4392184

Miraj S, Alesaeidi S. A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile). Electronic Physician 2016;(8):3024-31. http://doi.org/10.19082/3024

Rao S, Hegde S, Beliga-Rao M, Palatty P, George T, Baliga M. An aloe vera-based cosmeceutical cream delays and mitigates ionizing radiation-induced dermatitis in head and neck cancer patients undergoing curative radiotherapy: a clinical study. Medicines (Basel) 2017;(3):44. https://doi.org/10.3390/medicines4030044

Union for International Cancer Control. In: Brierley JD, Gospodarowicz MK, Wittekind C, eds. The TNM classification of malignant tumours. 8th ed. Wiley Clackwell:2017. 272 p.

Brasil. Ministério da Saúde, Portaria Conjunta nº 04, DE 23 de janeiro de 2018. [Citado em 2019 mar 03]. Disponivel em: https://portalarquivos2.saude.gov.br/images/pdf/2018/fevereiro/07/PORTARIA-no-04-PCDT.carcinoma.mama.2018.pdf




DOI: http://dx.doi.org/10.33233/eb.v19i3.2351

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